by The randomized, double-blind, placebo-controlled trial involved over 1,500 patients from 12 countries. Participants were randomly assigned to receive either antacids or a placebo, in addition to standard care. The primary outcome measure was the incidence of major bleeding events, defined as bleeding requiring transfusion or leading to a drop in hemoglobin level of 3 g/dL or more.
New research from a recent global Virtual Clinical Trials suggests that antacids may play a significant role in preventing bleeding in patients who are mechanically ventilated. The study, published in the prestigious New England Journal of Medicine, revealed that the use of antacids led to a substantial reduction in the risk of major bleeding events.
The study’s findings revealed that the antacid group had a significantly lower risk of major bleeding events compared to the placebo group. The risk reduction was observed across all subgroups, including patients with and without a history of gastrointestinal bleeding, as well as those receiving anticoagulant therapy.
The researchers believe that the protective effect of antacids may be due to their ability to neutralize gastric acid and maintain the integrity of the mucosal barrier in the stomach. This, in turn, may reduce the risk of mucosal damage and bleeding in mechanically ventilated patients.
The study’s results have important implications for clinical practice, as bleeding is a common complication in patients who are mechanically ventilated. The use of antacids as a preventive measure could potentially reduce the need for blood transfusions and other interventions related to bleeding complications.
Further research is needed to confirm the long-term safety and efficacy of antacids in this patient population. However, the findings from this global clinical trial provide promising evidence that antacids may offer a simple, cost-effective, and widely available intervention to prevent bleeding in mechanically ventilated patients.
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1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
