by The technique allows for isolation of desired biomolecules and removal of impurities, cell debris and media components. It helps recover intracellular and secreted recombinant proteins, vaccines and enzymes among others. The advantages of downstream processing include obtaining purified products through techniques like centrifugation, filtration and chromatography while reducing production costs. Rising demand for biologics in healthcare has supplemented the need for high-yield purification and recovery systems in downstream processing.
The Global Downstream Processing Market is estimated to be valued at US$ 246.2 Mn in 2024 and is expected to exhibit a CAGR of 2.6% over the forecast period 2024 to 2031.
Key Takeaways
Key players: Key players operating in the downstream processing market are Merck KGaA, Thermo Fisher Scientific Inc., GE Healthcare, Sartorius Stedim Biotech S.A., Repligen Corporation, Pall Corporation, M Company, Eppendorf AG, Agilent Technologies, Inc., Waters Corporation, Shimadzu Corporation, Bio-Rad Laboratories, Inc., Avantor Performance Materials, LLC, Tosoh Corporation, Column Technology Inc., Purolite, W.R. Grace & Co., Asahi Kasei Corporation, Novasep Holding S.A.S, and Boehringer Ingelheim.
Growing demand: Rapid advancements in medical biotechnology have increased demand for effective purification of biotherapeutic drugs and vaccines. Growing incidence of chronic diseases is prompting pharmaceutical manufacturers to invest in mass production facilities relying on robust downstream processing solutions.
Global expansion: Key players are expanding their geographical footprint through strategic mergers and acquisitions. For instance, Sartorius acquired selected Danaher businesses to strengthen its position in filtration, purification and laboratosy businesses. Similarly, Thermo Fisher acquired clinical research company PPD to enhance its genome and cell therapy portfolio.
Market key trends
One of the key trends in the Downstream Processing Market Demand is the growing focus on single-use technologies. Single-use systems are preferred over conventional stainless-steel equipment as they reduce capital costs, minimize downtime and also prevent cross-contamination. Similarly, the integration of novel chromatographic techniques with automation is gaining traction as it allows for continuous processing and higher product yields. Other notable trends include the development of membrane adsorbers for cost-effective purification and the advent of modular facility designs for contract service providers.
Porter’s Analysis
Threat of new entrants: Downstream Processing requires significant capital investment for infrastructure facilities and manufacturing equipment which poses high entry barriers for new players.
Bargaining power of buyers: Specific technical expertise and stringent regulatory compliances give limited options to buyers, reducing their bargaining power.
Bargaining power of suppliers: Established industry players source raw materials from few specialized suppliers globally increasing supplier bargaining power.
Threat of new substitutes: Limited substitutes due to specialized downstream processing needs.
Competitive rivalry: Intense competition among major multinational players to gain higher market share through acquisitions and innovations.
Geographical Regions
North America dominated the global downstream processing market in terms of value in 2024 due to significant spending on research activities in pharmaceutical and biotechnology industries in the US and Canada. Growing trend of outsourcing manufacturing in the region also supplements the market growth.
Asia Pacific region is expected to grow at the fastest rate during the forecast period 2024-2031. Expanding pharmaceutical manufacturing facilities and improving regulatory framework in emerging economies like China and India offer huge potential for downstream processing products and services in the region. Growing biosimilars market and increasing population also propels the regional market.
*Note:
1.Source: Coherent Market Insights, Public sources, Desk research
2.We have leveraged AI tools to mine information and compile it
About Author:
Money Singh is a seasoned content writer with over four years of experience in the market research sector. Her expertise spans various industries, including food and beverages, biotechnology, chemical and materials, defense and aerospace, consumer goods, etc. (https://www.linkedin.com/in/money-singh-590844163)
